Endocrine Abstracts

IntroductionMenopausal transition is associated with an increase in the cardiovascular risk, possibly related with the sharp decrease of estrogen levels. Menopausal symptoms and more specifically hot flushes have been previously linked with an increase in cardiovascular risk. On the other hand, non-alcoholic fatty liver disease is considered as another presentation of the metabolic syndrome, conferring additional cardiovascular risk to the affected indiv...

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

Objective: Kidney function is known to be interrelated with the aging process. On the other hand, a number of studies support a link between the menopausal transition and kidney function, either directly or indirectly, secondary to the effect of the alternating hormone environment or the effect of the accumulated cardiovascular risk factors, respectively. We aimed to evaluate the cross-sectional association between kidney function and sex hormones at the time of the menopausal...

Background: Cardiovascular disease remains the leading cause of death worldwide, affecting both sexes. Awareness and prevention practices aiming to control cardiovascular risk in women remain inadequate. On the other hand, circulating amyloid β 1-40 (Aβ1-40) is a proatherogenic peptide, closely linked with the process of aging. We aimed to evaluate the possible association between the progression of atherosclerosis in postmenopausal women and the role of Aβ1-40 ...

Background: A large body of evidence is supporting that the incidence of adverse cardiovascular events is increasing signfiicantly after the menopausal transition. Primary prevention practices continue to propose evolving algorithms, in an attempt to accurately estimate the actual female cardiovascular risk at midlife. Irrespectively of these attempts, considerable unrecognized cardiovascular disease (CVD) risk remains unexplained, beyond traditional risk factors (TRFs). On th...

Background: Both surgical and spontaneous menopause are associated with increased cardiovascular disease (CVD) risk. Recent evidence reported that clusters of menopausal symptoms are associated with accumulation of cardiometabolic risk factors. Climacteric symptoms are also known to be affected by lifestyle parameters, ethnicity, the geographical location as well as by the overall health status at the time of the menopausal transition.Aim: This study aim...

Objective: To evaluate the association between genetic background and the presence of oligo- or amenorrhea in a sample of adolescent girls diagnosed with anorexia nervosa compared with controls.Methods: A total of 40 adolescent girls diagnosed with anorexia nervosa aged 14–17 years, as well as 10 age-matched girls, were included in the study. We recorded anthropometric parameters and calculated body mass index (BMI) z-scores adjusted for age, as wel...

Introduction: The aim of this study was to evaluate the association between a personal history of lactation and indices of subclinical atherosclerosis and arterial stiffness in postmenopausal women.Patients and methods: This cross-sectional study included 283 postmenopausal women. Sonographically assessed indices of vascular function [pulse wave velocity (PWV)] and vascular structure [intima-media thickness (IMT), atherosclerotic plaque presence] were te...

Introduction: A growing body of evidence is supporting a beneficial impact of breastfeeding on maternal metabolism and overall cardiovascular risk. The aim of this study was to evaluate the association between prolactin levels and metabolic parameters as well as indices of subclinical atherosclerosis, in a sample of premenopausal women with normal levels of prolactin.Patients and Methods: This cross-sectional study included a total of 64 non-lactating pr...

Introduction: The aim of this study was to investigate the incidence of hypertension and to identify potential risk factors in healthy, non-diabetic recently postmenopausal Greek women with normal renal function.Patients and methods: In this retrospective cohort study, we evaluated 141 recently postmenopausal women at baseline and annually thereafter (follow-up time: 1 to 8 years). Blood samples were obtained and ultrasound evaluations were performed at ...